|
T2710 |
TCS 1102
|
DORA-1 |
OX Receptor
|
|
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors). |
|
T77676 |
(Z)-Metanicotine 2HCl
|
(Z)-Metanicotine 2HCl(1129-68-6 Free base) |
Others
|
|
(Z)-Metanicotine 2HCl has analgesic activity and is used in the treatment of central system disorders. |
|
T1413 |
Pentetrazol
|
Metrazole,Pentylenetetrazole,Pentylenetetrazol,PTZ,pentamethylenetetrazol,Cardiazol |
GABA Receptor
|
|
Pentylenetetrazol is a GABA(A) receptor antagonist, that displays activity as a central nervous system and respiratory stimulant. |
|
T68127 |
Picenadol
|
LY-150720,LY150720,LY 150720 |
Others
|
|
Picenadol (LY 150720) is a racemic mixture of N-methyl-4-phenylpiperidine derivatives with agonist-antagonist opioid properties.Picenadol has central analgesic activity. |
|
T1946 |
Felbamate
|
W-554,ADD-03055 |
NMDAR
,
iGluR
|
|
Felbamate (W-554) is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
|
T6445 |
Cilomilast
|
SB-207499,Ariflo |
PDE
|
|
Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3. |
|
T77731 |
ERK5-IN-6
|
|
ERK
|
|
ERK5-IN-6 is a potent inhibitor of ERK5 kinase.ERK5-IN-6 exhibits antiproliferative activity, anticonvulsant activity, and antitumor activity, and can be used in the study of central nervous system-related disorders. |
|
T0440 |
Oxcarbazepine
|
GP 47680 |
Apoptosis
,
Sodium Channel
|
|
Oxcarbazepine (GP 47680) is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
|
T2407 |
Tiagabine
|
TGB,NO050328,Gabitril,NO328 |
GABA Receptor
|
|
Tiagabine (NO050328) is an Anti-epileptic Agent. The physiologic effect of tiagabine is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
|
T6649 |
(S)-(+)-Rolipram
|
(S)-Rolipram,(+)-Rolipram,S- (+)-Rolipram |
Apoptosis
,
PDE
|
|
(S)-(+)-Rolipram ((+)-Rolipram) inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer. |
|
T0680 |
Lamotrigine
|
LTG,BW430C |
5-HT Receptor
,
Sodium Channel
,
Autophagy
|
|
Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
|
T0806 |
Flunarizine dihydrochloride
|
Flunarizine 2HCl,KW-3149,R14950 |
Calcium Channel
,
Dopamine Receptor
,
Sodium Channel
|
|
Flunarizine dihydrochloride (R14950) is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. Flunarizine dihydrochloride (R14950) is effective in the prophylaxis of mig... |
|
T2156 |
WP1066
|
|
Apoptosis
,
JAK
,
STAT
|
|
WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 has been used in trials studying the treatment of Melanoma, Bra... |
|
T16115 |
MLi-2
|
|
LRRK2
|
|
MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a ce... |
|
T1790 |
Fosaprepitant dimeglumine
|
L785298,MK-0517,Fosaprepitant dimeglumine salt |
Neurokinin receptor
|
|
Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion... |
|
T26778 |
Besipirdine
|
HP 749 free base,P-867493,P867493,HP 749,HP749,P 867493 |
Sodium Channel
,
Adrenergic Receptor
|
|
Besipirdine (HP 749 free base) is a non-receptor-dependent cholinomimetic compound with alpha-adrenergic and cardiovascular activities.Besipirdine inhibits voltage-dependent sodium-potassium channels and inhibits biogeni... |
|
T10893 |
CS-722 Free base
|
|
Others
|
|
CS-722 Free base is a synthetic central muscle relaxant with muscle relaxant activity and inhibitory effect on spinal reflex. CS-722 Free base may inhibit spontaneous inhibitory post-synaptic current and excitatory post-... |
|
T1483 |
Citalopram hydrobromide
|
Lu 10-171,Nitalapram HBr,Bonitrile HBr,XU-62-320,Lu 10-171 HBr,Citalopram HBr |
5-HT Receptor
,
Serotonin Transporter
,
Autophagy
|
|
Citalopram hydrobromide (XU-62-320) , a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system... |
|
T7656 |
Apelin-13
|
|
|
|
Apelin-13 is a 13-amino acid peptide sequence found in the central and peripheral nervous system that is an endogenous ligand for the G protein-coupled receptor angiotensin II protein J (APJ), with an EC50 value of 0.37 ... |
|
T3716 |
Rolapitant
|
SCH619734 |
Neurokinin receptor
|
|
Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. ... |
|
T6426 |
Buclizine dihydrochloride
|
Longifene,Buclina,Buclizine HCl,UCB-4445 |
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Buclizine dihydrochloride (Buclina) is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine dihydrochloride binds to and ... |
|
T13330 |
WAY-213613 hydrochloride
|
WAY-213613 hydrochloride (868359-05-1 free base) |
transporter
|
|
WAY-213613 hydrochloride is a potent, selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 with IC 50 of 85 nM. WAY-213613 hydrochloride inhibits EAAT1 and EAAT3 with IC50 values of 5 and 3.8 microM, respectively. WA... |
|
T23440 |
TC-N 22A
|
|
GluR
|
|
TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier. EC50 expression of TC-N 22A in BHK cells expressing human mGlu4 was 9 nM. TC-N 22A showed very... |
|
T61025 |
GSK-1482160
|
|
P2X Receptor
|
|
GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflammatory cytokines by central and peripheral immune cells, so G... |
|
T0455 |
Clozapine
|
HF 1854,LX 100-129 |
Dopamine Receptor
,
Adrenergic Receptor
,
AChR
|
|
Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a... |
|
T68599 |
Orphenadrine
|
Orphenadrine (free base) |
Sodium Channel
,
NMDAR
,
AChR
|
|
Orphenadrine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits clonal HERG channels in a concentration-dependent manner, producing an IC of 0.85 μM in HEK cells.Orphenadrine is an antagoni... |
|
T73342 |
Prenderol
|
2,2-Diethyl-1,3-propanediol |
|
|
Prenderol, a potent central-nervous-system (CNS) depressant, exhibits anticonvulsant activity. |
|
T27379 |
FR-194921
|
FR194921 |
|
|
FR-194921 is a potent, selective, and orally active antagonist for central adenosine A1 receptors with cognitive-enhancing and anxiolytic activity. FR194921 has same binding affinity profile among human, rat, and mouse. |
|
T71160 |
Levomepromazine HCl
|
|
|
|
Levomepromazine HCl is a phenothiazine with pharmacological activity similar to that of both CHLORPROMAZINE and PROMETHAZINE. It has the histamine-antagonist properties of the antihistamines together with CENTRAL NERVOUS... |
|
TP2139 |
AMY-101
|
Cp40 |
Others
|
|
AMY-101 is a peptidic inhibitor of the central complement component C3 (KD: 0.5 nM). AMY-101 shows a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation. |
|
TP2194 |
Neuropeptide Y (scrambled)
|
|
Others
|
|
Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that exerts its activity via G-protein-coupled receptors. NPY is widely distributed in the peripheral and central nervous systems. It modulates a variety of physiologi... |
|
T36644 |
Rezivertinib
|
|
|
|
Rezivertinib (BPI-7711) is an orally active, highly selective and irreversible third-generation EGFR tyrosine kinase inhibitor (TKI) with potent activity against both common activation EGFR and resistance T790M mutations... |
|
TP2139L |
AMY-101 TFA
|
Cp40 TFA |
Others
|
|
AMY-101 TFA (Cp40 TFA) is a peptidic inhibitor of the central complement component C3 (KD: 0.5 nM). AMY-101 TFA shows a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper in... |
|
T40473 |
RCRAMP (rat)
|
|
|
|
rCRAMP (rat), the rat cathelin-related antimicrobial peptide, plays a crucial role in the antibacterial activity found in rat brain peptide/protein extracts. As a potential key player in the innate immune system of the r... |
|
T61427 |
Lamivudine salicylate
|
|
|
|
Lamivudine (BCH-189) salicylate is an orally active nucleoside reverse transcriptase inhibitor (NRTI) that effectively inhibits the reverse transcriptase activity of both HIV 1/2 and hepatitis B virus. Moreover, it demon... |
|
T37182 |
AX 048
|
|
|
|
The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid from membrane phospholipids, playing a central role in initiating the synthesis of prostagla... |
|
T38049 |
Glycerophospho-N-Palmitoyl Ethanolamine
|
|
|
|
N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. For example, arachidonoyl ethanolamide (AEA) is an endogenous neurotransmitter that evokes cellular responses by activating t... |
|
T29938 |
AM-3102
|
KDS-5104,AM 3102,Methyl oleoylethanolamide |
|
|
AM-3102 is an OEA analog that stimulates PPARα transcriptional activity and prolongs feeding latency. It is resistant to enzymatic hydrolysis and is as potent as OEA in enhancing transcriptional activity of PPARα and red... |
|
T36591 |
ABD459
|
|
|
|
ABD459 is a neutral antagonist of the central cannabinoid 1 (CB1) receptor (Ki = 8.6 nM). It inhibits food consumption in nonfasted mice without affecting motor activity. ABD459 reduces active food seeking for 5-6 hours ... |
|
T61784 |
GlcN-6-P Synthase-IN-1
|
|
|
|
GlcN-6-P Synthase-IN-1 (Compound 4d) is a potent inhibitor of Glucosamine-6-phosphate (GlcN-6-P) synthase, with an IC50 of 3.47 μM. This compound demonstrates remarkable antimicrobial activity and exhibits excellent pene... |
|
T73655 |
Frakefamide TFA
|
|
|
|
Frakefamide TFA is a potent analgesic functioning as a μ-selective receptor agonist with peripheral activity. Notably, Frakefamide cannot cross the blood-brain barrier to enter the central nervous system [1] [2]. |
|
T76440 |
Peptide E
|
|
|
|
Peptide E, a potent kappa opiate receptor agonist, exhibits opiate receptor binding activity with an IC50 value of 0.39 μM, making it valuable for central nervous system research [1] [2]. |
|
T60445 |
Desipramine
|
|
|
|
Desipramine is a tricyclic psychotic compound with antidepressant activity. Desipramine inhibits the norepinephrine reuptake receptor in the central nervous system and reduces the sleep-related loss of genioglossus activ... |
|
T79297 |
DZD1516
|
|
EGFR
|
|
DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in both central nervous system (CNS) and subcutaneous xenograft mouse mo... |
|
T36813 |
Lu AE98134
|
|
|
|
Lu AE98134, an activator of voltage-gated sodium channels, acts as a partly selective Nav1.1 channels positive modulator. Lu AE98134 also increases the activity of Nav1.2 and Nav1.5 channels but not of Nav1.4, Nav1.6 and... |
|
TP2049 |
CRSP-1
|
|
|
|
Endogenous central calcitonin (CT) receptor agonist that stimulates cAMP formation at a potency 350-fold greater than CT (ED50 values are 0.2 and 71 nM respectively). Displays no activity at calcitonin-gene related pepti... |
|
T38005 |
P11149
|
|
|
|
P11149, a derivative of Galanthamine, acts as a competitive, orally active, and selective AChE inhibitor with the ability to weakly penetrate the blood-brain barrier (BBB). It demonstrates selective inhibition, exhibitin... |
|
T62215 |
Tandospirone hydrochloride
|
|
|
|
Tandospirone (SM-3997) hydrochloride is a potent, selective 5-HT1A receptor partial agonist (Ki: 27 nM) that exhibits anxiolytic and antidepressant activity. tandospirone hydrochloride can be used to study central nervou... |
|
T68371 |
Rolapitant hydrochloride hydrate
|
|
|
|
Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant compe... |
|
T74863 |
Anthramycin
|
|
|
|
Anthramycin, a potent antibiotic and member of the pyrolobenzodiazepine (PBD) family, exhibits significant antitumor activity. Additionally, it functions as a potent antagonist of cholecystokinin in the central nervous s... |
